What is rTG Fish Oil and Why?
What is rTG Fish Oil and Why?
Because fish oil naturally contains a lower concentration of EPA and DHA, two types were developed to deliver higher levels of these beneficial nutrients in fewer doses—ethyl ester (EE) and re-esterified triglycerides (rTG).
Based upon one of the largest, independent studies conducted recently, as well as input from our customers, Focus Relief Plus now utilizes the rTG form.4 rTG takes the synthetic EE form of omega-3 and converts it back to its natural triglycerides (TG) form. This not only allows the delivery of concentrated omega-3, but ensures that absorption is optimized. Additionally, the added bioavailability benefit of rTG fish oil, though conflicting studies exist, outweighs that of an EE fish oil5 and is preferred by the majority of ophthalmologists.
- 4. Visioli F, Rise P, Barassi MC, et al, Dietary intake of fish vs. formulations leads to higher plasma concentrations of n-3 fatty acids. Lipids. 2003 Apr;38(4):415-8.
- 5. These claims are referenced in Asbell PA, Maguire MG, Peskin E, Bunya VY, Kuklinski EJ; Dry Eye Assessment and Management (DREAM©) Study Research Group. Dry Eye Assessment and Management (DREAM©) Study: Study design and baseline characteristics. Contemp Clin Trials. 2018 Aug;71:70-79. doi: 10.1016/j.cct.2018.06.002. Epub 2018 Jun 6.
What is GLA?
GLA is an Omega 6 Anti-Inflammatory Nutrient
The Omega 6 GLA has gained recognition over the last few decades for its anti-inflammatory and anti-cancer actions. Some key findings from controlled clinical trials include:
- In arthritics, several trials report that GLA reduced inflammation, symptoms, and the requirement for NSAIDs
- In inflammatory dry eye, GLA improved symptoms and reduced inflammation; in PRK patients, GLA relieved symptoms, and increased tear production and clearance; in Sjögren’s patients, GLA eased ocular discomfort by reducing inflammation and increasing tear content of PGE1
- In diabetics, GLA improved nerve conduction velocity leading to improved blood flow and reduced tingling of extremities
- In patients with acute lung injury, GLA along with EPA improved gaseous exchange
- In breast cancer patients, GLA improved the effectiveness of tamoxifen, reduced side-effects, and hastened therapeutic response
- In uremic pruiritis, a common problem in hemodialysis patients, topically applied GLA relieved symptoms (Abreu, 2017)
- Schnebelen C, Viau S, Grégoire S, Joffre C, Creuzot-Garcher C, P, Bron A, M, Bretillon L, Acar N: Nutrition for the Eye: Different Susceptibility of the Retina and the Lacrimal Gland to Dietary Omega-6 and Omega-3 Polyunsaturated Fatty Acid Incorporation. Ophthalmic Res 2009;41:216-224. doi: 10.1159/000217726
- Creuzot-Garcher C, Baudouin C, Labetoulle M, et al. Efficacy assessment of Nutrilarm, a per os omega-3 and omega-6 polyunsaturated essential fatty acid dietary formulation versus placebo in patients with bilateral treated moderate dry eye syndrome. J Fr Ophtalmol. 2011;34:448-455.
- THE IMPORTANCE OF OMEGA 6 INCLUDING GLA AN ANTI-INFLAMMATORY NUTRIENT: Jolie Abreu (2017) Blog, Cherab, Education, Featured, Fish Oil Information, Nutrition News, Parenting Special Needs, Pursuit, Research, Research Of Interest, Science, Therapy;
As a dietary supplement, take three (3) softgels daily with a meal.
Highly Refined and Concentrated Omega-3 Fish Oil (anchovy, sardine, mackerel), Capsule Shell (beef sourced gelatin, glycerin, purified water, fruit and vegetable color, citric acid), Borage Oil, Natural Lemon Flavor, Proprietary Antioxidant Blend (natural mixed tocopherols (soy), rosemary extract, and ascorbyl palmitate).
How long does the bottle last and how many do I take per day?
1 bottle contains 90 softgels, lasting 30 days when taken 3 times per day. Patients should always consult their physicians on instructions.
Who should take Focus Relief Plus®?
Those suffering from occasional dry eye symptoms, sourcing from a number of environmental, genetic, and post-operative factors. Focus Relief Plus contains fish oil concentrates. These fish oils are in rTG (re-esterified triglyceride) form, containing 1080mg of EPA and 420mg of DHA per day—levels shown to play a critical role in helping produce healthier tears. (Bhargava, 2013) (Macsai, 2008) (Kangari H, 2013)
Additionally, NEI has commented and supported the conclusions on a large-scale study that shows benefit to those type 2 diabetic patients who may be at risk of diabetic retinotopy (Chew, 2017). This study showed:
“In middle-aged and older individuals with type 2 diabetes, intake of at least 500 mg/d of dietary LCω3PUFA, easily achievable with 2 weekly servings of oily fish, is associated with a decreased risk of sight-threatening DR. Our results concur with findings from experimental models and the current model of DR pathogenesis.” (Sala-Vila A 2016)
Bhargava, K. K. (2013). A randomized controlled trial of Omega-3 fatty acids in dry eye syndrome. Santosh Medical College and Hospital, Department of Ophthalmology. Ghaziabad: Int J Ophthalmol.
Macsai, M. (2008). The role of Omega-3 dietary supplementation in blepharitis and meibomian gland dysfunction (an AOS thesis). Northwestern University Feinberg School of Medicine, Department of Ophthalmology. Chicago: Tans Am Opthalmol Soc.
Kangari H, E. M.-B. (2013). Short-term consumption of oral Omega-3 and dry eye syndrome. Shahid Beheshti University of Medical Sciences, Department of Optometry. Tehran: Ophthalology. doi:10.1016/j.ophtha.2013.04.006
Chew (2017). Dietary Intake of Omega-3 Fatty Acids From Fish and Risk of Diabetic Retinopathy
Sala-Vila A, Díaz-López A, Valls-Pedret C, et al. Dietary Marine ω-3 Fatty Acids and Incident Sight-Threatening Retinopathy in Middle-Aged and Older Individuals With Type 2 DiabetesProspective Investigation From the PREDIMED Trial. JAMA Ophthalmol. 2016;134(10):1142–1149. doi:10.1001/jamaophthalmol.2016.2906
Are Focus Vitamins safe for my patients?
Every product is exclusively produced in NSF certified and FDA audited facilities for cGMP (Good Manufacturing Practice) compliance. Numerous consumer advocate and public health organizations, including the Council for Responsible Nutrition and Consumer Reports, recommend patients seek NSF or similar third-party certification prior to purchase. (Interlandi, 2016)
We go beyond industry requirements by conducting and approving a certification of analysis (COA) prior to distribution for every active ingredient, on every lot, every time. Lots are also tested by third party labs to ensure our manufacturing claims are correct, but also validate stability and expiration dating. Expiration dating for the new Focus Relief Plus® will be 2 years from date of manufacture and will be printed on the bottle.
Interlandi, J. (2016, September). Supplements: A Complete Guide to Safety. Consumer Reports, pp. 20-33.
Why 3 times per day?
Focus Relief Plus® was designed for three doses per day to allow patients to conveniently take the supplement with meals, preferably high in healthy fats. Clinical studies have shown that absorption improve three-fold when taken with high-fat meals. (Lawson LD H. B., 1988)
Lawson LD, H. B. (1988). Absorption of eicosapentaenoic acid and docosahexaenoic acid from fish oil triacylglycerols or fish oil ethyl esters co-ingested with a high-fat meal. Springville: Biochemical and Biophysical Research Communications.